A MAPK Scaffold Lends a Helping Hand
نویسندگان
چکیده
The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.
منابع مشابه
RACK1, scaffolding a heterotrimeric G protein and a MAPK cascade.
Scaffold proteins of mitogen-activated protein kinase (MAPK) cascades play crucial roles in determining signal specificity, amplitude, and duration in yeast and mammals. Recently, RACK1 was identified as the first plant MAPK scaffold protein that connects heterotrimeric G protein with a MAPK cascade to form a unique signaling pathway in plant immunity.
متن کاملDifferential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes.
Pathway specificity is poorly understood for mitogen-activated protein kinase (MAPK) cascades that control different outputs in response to different stimuli. In yeast, it is not known how the same MAPK cascade activates Kss1 MAPK to promote invasive growth (IG) and proliferation, and both Fus3 and Kss1 MAPKs to promote mating. Previous work has suggested that the Kss1 MAPK cascade is activated...
متن کاملHow scaffolds shape MAPK signaling: what we know and opportunities for systems approaches
Scaffolding proteins add a new layer of complexity to the dynamics of cell signaling. Above their basic function to bring several components of a signaling pathway together, recent experimental research has found that scaffolds influence signaling in a much more complex way: scaffolds can exert some catalytic function, influence signaling by allosteric mechanisms, are feedback-regulated, locali...
متن کاملScaffold proteins in mammalian MAP kinase cascades.
The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to humans, is activated in response to a variety of extra- and intracellular stimuli, and plays key roles in multiple cellular processes, including proliferation, differentiation, and apoptosis. The MAPK pathway transmits its signal through the sequential phosphorylation of MAPK kinase kinase to MAPK ki...
متن کاملThe JIP family of MAPK scaffold proteins.
The components of MAPK (mitogen-activated protein kinase) signalling pathways can assemble into complexes that are co-ordinated by regulatory proteins including scaffold proteins. There is increasing evidence that scaffold proteins (i) maintain signalling specificity and facilitate the activation of pathway components, (ii) localize pathway components to particular subcellular sites or to speci...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 136 شماره
صفحات -
تاریخ انتشار 2009